OXIDATION AND AROMATIZATION OF THE ENANTIOPURE PIPERIDINE DERIVED FROM (R)-(-)-2-PHENYLGLYCINOL TO (1'R)-(-)-1-(2'-HYDROXY-l'-PHENYLETHYL)-1H-PYRIDIN-2-ONE

摘要

An efficient oxidation of enantiopure piperidine 1 with bromine in acetic acid to generate the corresponding enantiopure (R)-3,3-dibromo-1-(2'-hydroxy-1'-phenylethyl)piperidin-2-one 2 is described. Then, aromatization of compound 2 to give enantiopure pyridin-2-one 3 in 71% overall yield is presented.