HYDRAZONES AND 1,3-THIAZOLIDIN-4-ONES INCORPORATING FUROXAN MOIETY SYNTHESIZED FROM EUGENOL, THE MAIN CONSTITUENT OF OCIMUM SANTUM L. OIL

摘要

Two series of new hydrazones and l,3-thiazolidin-4-ones incorporating furoxan moiety were synthesized from eugenol, the main component of Ocimum sanctum L. oil. The structure of these compounds was determined by IR, MS, ~1H and ~(13)C NMR analysis. All resonance signals of proton and carbon in the examined compounds are assigned using HSQC, HMBC and NOESY spectra. The hydrazones and the l,3-thiazolidin-4-ones were tested for antimicrobial activities and almost all examined thiazolidinones displayed moderate activity against S. aureus and A. niger. Among screened hydrazones only one compound exhibited a significant cytotoxicity for human cancer cell line SW620.