ZIRCONIUM CATALYZED CHEMOSELECTTVE SYNTHESIS OF NEW AMIDO-SUBSTITUTED BENZO[b]FURANS VIA A ONE-POT REACTION

摘要

A one-pot, three-component reaction of arylglyoxals, benzamide and phenols using catalytic amounts of zirconium oxychloride octahydrate under solvent-free conditions produce new amido-substituted benzo[b]furans. The reactions showed chemoselectivity towards benzofuran instead of oxazols which this claim has been confirmed by nuclear magnetic resonance (NMR) and infrared spectroscopy (IR).