EXPANDING STRUCTURAL DIVERSITY OF TERPENE TRILACTONES FROM GINKGO BILOBA EXTRACT:STUDIES TOWARDS CORE-MODIFIED GINKGOLIDES

摘要

Ginkgolides,the unique terpene trilactones from the Ginkgo biloba tree,are believed to enhance memory,improve blood circulation and exhibit beneficial effects in the treatment of dementia.Unfortunately,mechanisms of ginkgolide actions at the molecular level are still not determined.Ginkgolide skeleton modifications may provide a plausible approach to address subtle changes in the ligand-receptor interactions.Furthermore,the simplified structure of the ginkgolide skeleton may guide to the leads that will be attractive for drug development.This review covers the modifications of the ginkgolide skeleton,reported to date.