Stereoselective total synthesis of the nonenolide (+)-microcasrpalide

摘要

The enantiomer [(+)-1]of the nonenolide natural product microcarpalide [(-)-1]has been prepared from (S)-malic acid 93)and 3-decyn-1-ol (11)via a sixteen step sequence involving,inter alia,two metathesisprocesses.In 2001hemscheidt et al.