A FACILE AND CONVENIENT SYNTHETIC METHOD FOR FLUORINE-CONTAINING 1,2-DIHYDROPYRIDO-[3,2-h]QUINAZOLINES AND PYRIDO[3,2-h]QUINAZOLINES

摘要

5,7-Bis(trifluoroacetyl)-8-quinolylamine (1) reacted with various aliphatic and aromatic alkehydes in the presence of aqueous ammonia to afford fluorine-containing 1,2-dihydropvrido[3,2-h]quinazolines (2) and pyrido[3,2-h]quinazoline-6-methanols (3) in moderate to high yidlds.Dehydrogenation of 2 with DDQ gave the corresponding pyrido-[3,2-h]quinazolines (4) in excellent yields.Conversion of alcohols (3) into hydrates (4) with DDQ was also successful.