Indoloquinones, Part 8.1 Palladium(Ii)-Catalyzed Total Synthesis Of Murrayaquinone A, Koeniginequinone A, And Koeniginequinone B

摘要

Regioselective addition of the appropriate arylamines to 2-methyl-l,4-benzoquinone followed by a palladium(II)-catalyzed oxidative cyclization opens up an efficient route to the naturally occurring 3-methylcarbazole-l,4-quinone alkaloids murrayaquinone A, koeniginequinone A, and koeniginequinone B.Numerous carbazole alkaloids with interesting structural features and useful pharmacological activities have been isolated from different natural sources over the past four decades. Because of the strong interest in these natural products several new methodologies directed towards their total synthesis were developed.