Synthesis of a 2-pyrrolidinol metabolite of OPC-51803,A vasopressin V_2 Receptor Agonist

摘要

The unstable 2-pyrrolidinol derivative (2),as a metabolite of a new vasopressin V_2 receptor agonist OPC-51803 (1),was synthesized by the cytochrome P-450 model reaction of 1 with the Fe-salen complex and iodosobenzene.