Synthesis of (S)-vasicol and (S)-3-hydroxy-2-pyrrolidinone

摘要

Starting from (S)-malic acid, a flexible approach to (S)-3-hydroxy-2-pyrrolidinone and (S)-1-alkyl-3-hydroxy-2-pyrrolidinones was reported. Using this method, the first total syntheses of (-)-vasicol as well as deaminovasicol were accomplished, which allowed the revision and clarification the confusion about the structure of naturally occurring (-)-vasicol.