Chemical constituents of pterocaulon redolens

摘要

Studies on the chemical constituents of the aerial parts of Pterocaulon redolens (Forst.f) F.Vill.(Asteraceae) resulted in the isoaltion of ten components:seven coumarins [5-methoxy-6,7-methylenedioxycoumarin (1),ayapin (2),puberulin (3),5-methoxyscopoletin (4),2',3'-dihydroxypuberulin (5),isofraxidin (6),and 5-(2',3'-dihydroxy-3'-methylbutyloxy)-6,7-methylenedioxycoumarin (7)] and three flavonoids [luteolin (8),tomentin (9),and chrysosplenol C (10)],among which 5 was firstly isolated as a nautral product.The full ~1H- and ~(13)C-NMR spectral assignments for the isolated products,including revision of previous assignment in the literature are reported.Six coumarins (1,4,6,and 7) and one flavonoid (8) displayed mild activity against Mycobacterium tuberculosis H_(37)Ra.In addition,flavonoid (10) was firstly found to possess moderate cytotoxicity against breast cancer (BC) and human small cell lung cancer (NC1-H187) cell lines.