Formal total synthesis of macrosphelide (+)-A, effect on macrolactonization depended upon the lactone formation position

摘要

Formal total synthesis of (+)-macrosphelide A (1) was achieved based on macrolationization via path B from a seco- acid (3) and path C from a seco-acid (4). The yield of macrolactonization via paths B and C were 18 and 59%, respectively.