CYTOCHROME C OXIDASE ACTIVE SITE MIMICS: NEW LIGANDS FOR COPPER AND AN UNEXPECTED OXIDATIVE C-C BOND FORMATION

摘要

Ligands that mimic the unusual active site polypeptide of cytochrome c oxidase have been prepared in overall good yield; structures of the corresponding Cu(II) complexes are secured by single crystal x-ray analysis. The key step in the synthesis of the ligands is the coupling of a suitable organolead(IV) phenol derivative with the N of the histidine imidazole ring. In the process of preparing crystals of a tridentate ester ligand an unusual oxidative C-C bond-forming reaction occurs that affords the imidazotetrahydropyridine ring system.