1,3-DIPOLAR CYCLOADDITIONS OF 2-tert-BUTOXYCARBONYL-1-PYRROLINE N-OXIDE WITH CHIRAL ACRYLATES AND ACRYLAMIDES

摘要

The 1,3-dipolar cycloadditions of a series of chiral acrylates and acrylamides with 2-tert-butoxycarbonyl-1-pyrroline N-oxide were studied.The synthesis of enantiopure tert-butyl(2R,7aR)-and(2S,7aS)-2-hydroxy-3-oxo-tetrahydro-1H-pyrrolizine-7a(5H)-carboxylates starting from the acryloyloxazolidinone derived from(S)-phenylalanine is reported.