CONVERGENT SYNTHESIS OF THE CDEF RING FRAGMENT OF YESSOTOXIN VIA alpha-CYANO ETHERS

摘要

The synthesis of the CDEF ring fragment of yessotoxin,a marine ladder polyether,has been achieved.Union of three components,the C ring aldehyde,the F ring diol,and trimethylsilyl cyanide,was accomplished by treatment with Sc(OTf)_3 to afford the alpha-cyano ether both in stepwise and one-pot reactions.The DE ring system was constructed through a ring closing metathesis reaction and reductive etherification sequence.