FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS OF THE MYXOBACTERIAL ANTIBIOTICS CYSTOTHIAZOLES

摘要

Eight derivatives of the bithiazole-type myxobacterial antibiotic cystothiazole A were evaluated for antifungal activity against a phytopathogenic microorganism for a further structure-activity relationship.Two of them,an acetate and a fully conjugated non-chiral derivative,were new derivatives obtained by chemical derivatization of cystothiazole C.The results confirmed the importance of the bend conformation at C-4/C-5,the methyl ether at C-5,and the lipophilicity of the terminal alkyl group of the molecule.