Natural macrosphelides are known as potent cell-cell adhesion inhibitors,which have novel three ester linkages in their 16-membered macrocyclic skeleton.In this review,recent synthetic studies of macrosphelides and relating compounds are surveyed,mainly including our approaches.Since the first isolation and characterization in 1995,macrosphelides have received much attention from biochemists and synthetic chemists due to their notable bioactivities and novel structural characteristics.To date,twelve members of macrosphelide family have been isolated from Microsphaeropsis sp.FO-5050 and/or Periconia byssoides OUPS-N133,which were designated macrosphelides A-L(Figure I).
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