Synthesis of new medium ring aromatic lactones via halocyclization of 2-hydroxyphenylalkanoic acid allylic esters

摘要

Stable medium size ring aromatic lactones have been synthesized through electrophilic heteroatom cyclization reaction sin moderate yields.The synthesis of seven and largeer membered heterocyclic compounds from linear substrates,albeit a difficult process,has been well established,with the methodology of electrophilic heteroatom cyclization being among the most widely used approaches.