Synthesis of 2-substituted 3,4-dihydroquinazoline derivativesVia Regioselective addition of a Carbon nucleophile to a carbodiimide

摘要

synthesis of 2-alkyl or phenyl-substituted 3,4-dihydroquinazoline derivatives(6) isdescirbed via regioselective carbon nucleophilic addition(RMgBr) and RM) to a carodiimide (4) followed by intramolecular conjugate addition.