Heterocycle fused cyclohexylglycine derivatives as novel dipeptidyl peptidase-iv inhibitors

摘要

A new class of potent inhibitors of dipeptidyl peptidase IV (DP-IV)for the treatment of type II diabetes are described.Presented herein is the synthesis of indole-fused and thiazole-fused cyclohexylglycines.Pyrrolidine-derived amides of these novel heteroxycles led to the discover of thiazole derivative (3f)and (11a),both low nanomolar inhibitors of DP-IV (IC_50=6 nM).