Synthesis of various macrosphelides by oxidative derivatization of the macrosphelide core

摘要

The macrosphelide core (4),simple 16-membered trilactone,was subjected to several oxidative conditions to produce various natural macrosphelide analogues,including macrosphelides A and C.This approach provided a new access to diverse macrosphelides for a study on their structure-activity relationships.