STUDIES ON ISOCYANIDES AND RELATED COMPOUNDS.A FACILE SYNTHESIS OF 1-SUBSTITUTED 3-CYANO-2-METHOXY-3-PHENYL-PYRROLES

摘要

A simple one-pot synthesis of 1-substituted 3-cyano-1,2-dihydro-2-oxo-4-phenyl-2H-pyrroles (8) based on the isocyanide chemistry is described.Compounds (8) undergo a facile O-methylation with diazomethane to give the corresponding 1-substituted 3-cyano-2-methoxy-4-phenylpyrroles (1).