PROGRESS IN TOTAL SYNTHESIS OF MARINE ALKALOIDS,AAPTAMINES

摘要

A bright yellos aaptamine,which possesses a novel 1H-benzo[d ,e][1,6]naphthyridine skeleton was isolated as a protonic salt from the Okinawan sea sponge Aaptos aaptos.Also related compounds,demethylaaptamine and demethyloxyaaptamine were isolated from same origin .We summarize here eight total syntheses containing one formal synthesis of aaptamine and related compounds.