Amides from the Seeds of Piper Nigrum Linn. and Their Insecticidal Activity

摘要

Two new amides pipertidine (1) and pipercitine (2) have been isolated from the dried seeds of Piper migrum along with eight known constituents of beta-sitosterol, (2E, 4E, 8Z)-N-isobutyleicosatrienamide, pellitorine, guineensine, pipe-rine, piperettine, pipericine, and (3,4-methylenedioxyphenyl)cinnamaldehyde. The structures of 1 and 2 have been elucidated as 1-[8-(3',4'-methylenedioxyphenyl)-(7E)-octaenoyl]piperidine and 1-[(2E)-octadecenoyl]piperidine, through extensive spectral studies including 2D NMR. New compounds 1 and 2 and most of the known exhibited toxicity against fourth-instar larvae of Aedes aegypti.