PRACTICAL SYNTHESIS OF TRICYCLIC LACTAM MODEL OF ANTITUMOR RENIERAMYCIN-SAFRAMYCIN NATURAL PRODUCTS

摘要

practical synthesis of the tricyclic lactam model compound of antitumor renieramycin-saframycin natural product starting from 2-hydroxy-4,5-dimethoxy-3-methylbenzaldehyde in eleven steps was described. A tosyl group was used for protection of a phenol during this transformation. The overall yield of the target compound was 23%.