SYNTHESIS AND BIOACTIVITY OF PYRROLOINDAZOLES: AN OVERVIEW

摘要

In this review, the synthesis and bioactivity of pyrroloindazoles have been presented. The pyrroloindazoles were synthesised either by the heteroannulation of tetrahydro-indolones/isoindolones, aminoindazoles, Sonogashira/Cacchi indazolic substrates or acyl/aroylindole ketoxime dinitrophenyl ethers or by the cycloaddition of indolynes, indazolic betaines, styrylpyrazoles and nitroindazoles. Several pyrroloindazoles showed analgesic, antiinflammatory and antitumor properties, inhibition of Pim kinase and soluble guanylate cyclase, and antagonism of NMDA-receptor.