REGIO- AND ENANTIOSELECTIVE NITRONE CYCLOADDITION TO ALKYNONES FOR THE SYNTHESIS OF △~4-ISOXAZOLINES

摘要

We report herein a strategy for Lewis acid catalyzed enantioselective 1,3-dipolar cycloaddition of nitrones with alkynones to generate △~4-isoxazolines. The corresponding cycloadducts were isolated as a single regioisomer with high yields and enantioselectivities.