FACILE SYNTHESIS OF BENZIMIDAZO[2,1-a]ISOINDOLES FROM PHENOLIC ADDUCTS OF NINHYDRIN

摘要

An efficient synthesis of substituted benzimidazo[2,1-a]isoindoles via the reaction of phenolic adducts of ninhydrin with o-phenylenediamine in Et0H/AcOH under reflux conditions is achieved in single step. The process involves acid-catalyzed rearrangement followed by reaction with o-phenylenediamine.