REACTION OF 5-METHYLENEHYDANTOINS AND THEIR CHEMICAL MODIFICATION TO TWIN-DRUG TYPE SYMMETEICAL MOLECULES

摘要

We report chemical modifications of 5-methylenehydantoins (3a-e) with various amine nucleophiles to 5-substitutedhydantoins and transformations the obtained hydantoins to new symmetrical twin-drug type bivalent molecules 12 and 13. We also report 5-methylenehydantoin derivatives (3a) with some symmetrical diamines such as piperadine, ethylene-1,2-diamine, and 1,2-phenylenediamine. From trials using diamines such as ethylene-1,2-diamine and 1,2-phenylenediamine, hydantoin ring-opened products 10 and 11 were isolated predominantly.