A FORMAL PCB-FREE SYNTHESIS OF (-)-GSK1360707 VIA A DOUBLE ALKYLATION REACTION

摘要

The formal synthesis of the triple reuptake inhibitor (-)-GSK1360707 is described. The synthesis features an intramolecular cyclization and a double alkylation sequence to produce the 3-azabicyclo[4.1.0]heptane skeleton. An advantage of this route is the absence of PCB generation which plagued an earlier route.