ABSOLUTE STEREOSTRUCTURES OF 3S-PHYLLODULCIN,3R-AND 3S-PHYLLODULCIN GLYCOSIDES,AND 3R-AND 3S-THUNBERGINOL H GLYCOSIDES FROM THE LEAVES OF HYDRANGEA MACROPHYLLA SERINGE VAR.THUNBERGII MAKINO~1

摘要

A new dihydroisocoumarin,3s-phylloulcin,and nine new dihydroisocoumarin glycosides,3R- and 3S-phylloducin 3~'-O-glucosides,3R-and 3S-thunberginol H.8-O-glucosides,3R- and -3S-thunberginol I 4~'-O-glucosides,3R-and 3S-hydrangenol 4~'-O-apiosylglucosides,and thunberginol I 8-O-glucoside,were isolated from the leaves of Hydrangea macrophylla SERINGE var .thunbergii MAKINO.The absolute stereostructures of 3S-phyllodulcin,3R- and 3S-phyllodulcin 3~'-O-glucosides,and 3R-and 3S-thunberginol H 8-O-glucosides were elucidated on the chemical and physicochemical evidence.Phllodulcin from the unprocessed leaves was found to be ca,a5:1 enantiomer mixture at the 3-position.