GOULD-JACOB TYPE OF REACTION IN THE SYNTHESIS OF THIENO[3,2-e]PYRIMIDO[1,2-c]PYRIMIDINES: A COMPARISON OF CLASSICAL HEATING VS SOLVENT-FREE MICROWAVE IRRADIATION

摘要

Gould-Jacob type of reaction for the synthesis of thieno[3,2-e]pyrimido[1,2-c]pyrimidines (5) has been carried out conventionally by the con-desation between 4-aminothieno[2,3-d]pyrimidines (2) and diethyl ethoxymethyl-enemaloxate (3) via acyclic intermediates diethyl N-[5,6-disubstituted thieno[2,3-d]pyrimidin-4-yl]aminomethylenemalonates (4) and the results obtained were com-pared with single step microwave technique under solvent free conditions for the synthesis of 5.