Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin

Ji Hongyu; Tang Jingling; Li Mengting; Ren Jinmei; Zheng Nannan; Wu Linhua

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Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin

机译：具有Brij78和TPGS的姜黄素负载的固体脂质纳米颗粒可改善体内口服生物利用度和姜黄素的原位肠道吸收

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摘要

Purpose: The present study was to formulate curcumin solid lipid nanoparticles (Cur-SLNs) with P-gp modulator excipients, TPGS and Brij78, to enhance the solubility and bioavailability of curcumin.

机译：目的：本研究旨在用P-gp调节剂，TPGS和Brij78配制姜黄素固体脂质纳米颗粒（Cur-SLNs），以提高姜黄素的溶解度和生物利用度。

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《Drug delivery.》 |2016年第3期|共12页
作者
Ji Hongyu; Tang Jingling; Li Mengting; Ren Jinmei; Zheng Nannan; Wu Linhua;
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正文语种 eng
中图分类药学;
关键词
Curcumin; in situ intestinal absorption; oral bioavailability; P-glycoprotein; solid lipid nanoparticles;

机译：姜黄素;原位肠道吸收;口服生物利用度;P-糖蛋白;固体脂质纳米粒;

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1. Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin [J] . Ji Hongyu, Tang Jingling, Li Mengting, Drug delivery. . 2016,第1a3期

机译：具有Brij78和TPGS的姜黄素负载的固体脂质纳米颗粒可改善体内口服生物利用度和姜黄素的原位肠道吸收
2. Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability [J] . Sun J., Bi C., Chan H.M., Colloids and Surfaces, B. Biointerfaces . 2013,第Null期

机译：姜黄素负载的固体脂质纳米颗粒具有延长的体外抗肿瘤活性，细胞摄取并提高了体内生物利用度
3. Enhanced intestinal absorption of asenapine maleate by fabricating solid lipid nanoparticles using TPGS: elucidation of transport mechanism, permeability across Caco-2 cell line and in vivo pharmacokinetic studies [J] . Mitali Patel, Veenu Mundada, Krutika Sawant Artificial cells, nanomedicine, and biotechnology. . 2019,第1期

机译：通过使用TPGS制备固体脂质纳米颗粒来增强马来酸阿塞那平的肠吸收：阐明转运机制，跨Caco-2细胞系的通透性和体内药代动力学研究
4. THE IMPACT OF SOLUTOL HS 15 AND VITAMIN E-TPGS ON THE ORAL BIOAVAILABILITY OF COLCHICINE: PREDICTABILITY OF IN VIVO DATA FROM IN VITRO EXPERIMENTS? [C] . B. Bittner, T. Lave, A. Guenzi, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：SOLUTOL HS 15和维生素E-TPGS对可可霉素口服生物利用度的影响：可预测体外实验的体内数据？
5. Mechanistic Studies and Modeling of the Impact of Lipids and Emulsifiers on Oral Drug Absorption in vivo [D] . Speciner, Lauren. 2018

机译：机械研究与脂质和乳化剂抗冲击对体内口腔吸毒的影响
6. Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers [O] . Cihui Tian, Sajid Asghar, Yifan Wu, 2017

机译：通过牛磺胆酸修饰的纳米结构脂质载体改善姜黄素的肠道吸收和口服生物利用度
7. >99mTc Radiolabeled HA/TPGS-Based Curcumin-Loaded Nanoparticle for Breast Cancer Synergistic Theranostics: Design, in vitro and in vivo Evaluation [O] . Chong Huang, Fen Chen, Ling Zhang, 2020

机译：> 99m Tc基于放射性标记的Ha / Tpgs的姜黄素负载纳米粒子，用于乳腺癌协同治疗：设计，体外和体内评价

Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin

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