Magnetically Anisotropic Biodegradable Composites Based on Poly(3-Hydroxybutyrate) and Chitosan for Controlled Drug Release

摘要

Biodegradable polymeric compositions are widely used both in material science and in biomedicine [1,2]. Of particular interest is the development of composite materials for targeted and prolonged drug delivery. In order to increase the therapeutic efficiency of drugs, a procedure for their encapsulation into amphiphilic compositions based on poly(3-hydroxybutyrate) (PHB) and chitosan (CT) was developed [3, 4]. For the control of drug release rate, it is intended to introduce nanosized magnetite (Fe3O4) particles, as the type of their distribution in the matrix can be controlled by magnetic field [5, 6]. These composites represent a new class of biodegradable materials: magnetic biodegradable nanocomposites (MBNC) with controlled drug transport induced by magnetic field [7,8].