Synthesis of Hybrid Compounds Derived from Diterpene Alkaloid Lappaconitine

摘要

There has been growing interest in the design and synthesis of dimeric bases of different alkaloids after the structure and important pharmacological properties of dimeric alkaloids of isoquinoline (plant metabolites of genera Thalictrum and Berberis) [1] and indole types (from plants of genera Vinca, Strychnos, Iboga, and Catharantus [2, 3]) were established. Examples for modifications of morphinan alkaloids A-X are described that enable junction with the second molecule of alkaloid (A) through a linker (X) to form bivalent opioid ligands A-X-A. The latter show high selectivity in binding to receptors as compared with monovalent ligands A-X.