Synthesis of Diterpene Alkaloids of a New Structural Type from Maleopimaric Acid

摘要

The adduct of levopimaric acid with maleic anhydride, maleopimaric acid (1), widely used in the technology of paint and varnish and polymeric materials [1, 2], is considered as a promising starting material for the synthesis of biologically active compounds [3-5] and chiral ligands [6]. In this paper, we suggest a general approach to the synthesis of diterpene alkaloids of a new structural type based on maleopimaric acid. A nitrogen-containing group, which indicates that the new compounds are alkaloids, is represented by the amidine structural fragment.