Effect of Amino-Containing Polymers on the Photocatalytic Activity of Water-Soluble Porphyrin Sensitizers

摘要

Porphyrin photosensitizers (PPSs) immobilized on polymer carriers are used in both catalytic processes involving singlet oxygen (1O2) and photodynamic therapy (PDT) of tumors.The latter is due to their tumoro-tropism and biocompatibility.When used in PDT,1O2 oxidizes cell components and initiates a cascade of processes leading to the death of tumor cells.The possibility of using PPSs immobilized on biocompatible polymers,in particular,on natural polysaccharides,in PDT has been recently reported [1].However,it should be taken into account that polymers can sometimes modify the catalytic properties of PPSs.