Relationship between the Changes in Peripheral Thresholds of Nociception and Activity of the Adenylyl Cyclase System in the Skeletal Muscles of Rats with Streptozotocin-Induced Diabetes

摘要

Diabetic peripheral neuropathy (DPN) is the most severe and widely distributed complication of diabetes mellitus (DM). DPN may be diagnosed in more than half of patients with long history of the disease [ 11. The most common manifestation of DPN is symmetrical distal sensorimotor polyneuropathy, which is observed in 70% of cases [2]. Specific early signs of DPN are impairments of various types of sensitivity including nociception, which appear in distal parts of extremities and expand to their proximal parts. DPN is a chronic and progressive disorder. Modem therapy is aimed at prevention of progress of complications, but does not reduce developed degenerative changes [3]. In the case of insulin-dependent DM (type 1; DM1), the etiology of DPN has been well studied and considered to consist in metabolic impairments in nerves, which appear due to deficit of neurotrophic effects of insulin and C-peptide followed by long-term hyperglycemia [4]. Control of glucose level decreases the probability of DPN development by 60—70% |5]. However, studies on the early markers of development of diabetic neuropathy and its pathogenic mechanisms, specifically, neuropathic pain, are urgent problems of modem physiology and medicine.