Effect of the clathrate hydrate environment on the structure of collagen xenograft tissue with chitosan coating deposited from solution in the H2O/CO2 system at high pressure

摘要

The effect of the clathrate hydrate environment in the water/carbon dioxide system on the structure of the chitosan-coated collagen xenograft tissue was demonstrated. The collagen xenograft tissue treated in this environment is a porous material with a pore size of 50-500 nm having also micrometer size (1-3 mu m) pores. The high porosity results in averaging of the structural organization features in xenograft tissues with different orientation of collagen fibrils. Treatment of xenograft tissues in the H2O/CO2 environment in the presence of clathrate hydrates allows the manufacture of a nanoporous biodegradable material suitable for biomedical applications.