Indole-3-ylsulfonyl acetate tris-(2-hydroxyethyl)-ammonium is an effective antioxidant and cell membranes stabilizer.

摘要

The problem of leading Russian medications of the next generation for patients suffering from autoim mune diseases and secondary immunodeficiency (including that caused by viral/retroviral infection) and patients immunocompromised after Xray and chemotherapy, oncological diseases, injuries, severe burns, longterm chronic illnesses, etc. is of current interest. Previously, we showed that [1–5] indole3ylsulfo nyl acetate tris(2hydroxyethyl)ammonium 3Ind Sdegree CH2COO–N+H(CH2CH2OH)3 or indacetamine (INA) has high immune and erythropoiesisstimulat ing activities. In an in vitro culture, the substance dosedependently inhibits spontaneous and mitogen stimulated splenocyte proliferation by suppressing stimulated production of proinflammatory cytokines (IL1β, TNFα). In intact animals in vivo, INA signif icantly stimulates primary and secondary humoral immune responses and macrophage phagocytic activ ity, suppresses delayed hyperresponsiveness, and has significant effects on marrow hematopoietic progeni tors of erythropoiesis. The erythropoiesismodulating properties are expressed in hematocrit and hemato globulin normalization, elimination of reticulocytosis from peripheral blood, and effective impact on early steps of marrow erythroid progenitor’s differentiation. INA has a noticeable influence on the functional properties of hematopoietic stem cells, stimulates the growth of granuloid, and inhibits the growth of eryth roid colonies.