Water-soluble hypocrellin A nanoparticles as a photodynamic therapy delivery system

摘要

A novel delivery system for the hydrophobic photosensitizer,hypocrellin A,has been developed that uses hypocrellin A nanoparticles prepared by a reprecipitation method.In comparison to the unmodified photosensitizer,the hypocrellin A nanoparticles not only possess superior water solubility,higher water and light stability but also display high singlet oxygen production and DNA photocleavage capability.