The photosensitization activity of a water-soluble carboxylate of hypocrellin B

摘要

Based on theoretical prediction of the molecular polarity,water-soluble sodium HB-14-carboxylate(SCHB)was prepared and its photosensitization activity was evaluated.SCHB shows not only very good amphiphilicity but also much stronger absorption at 620 nm than its parents.In DMSO-PBS(3:1 by volume)solution(pH 7.4)of SCHB,the photosensitization generated the semiquinone anion radicals(SCHB~(centre dot-))under anaerobic condition or superoxide anion radicals(O_2~(centre dot-))in the presence of oxygen.In the oxygenated PBS solution of SCHB,hydroxyl radicals(~(centre dot)OH)were photogenerated.In addition,SCHB could also be photosensitized to generate singlet oxygen(~1O_2)with a quantum yield about 0.26.These findings suggest that SCHB can exert photodynamic action via photosensitization.