Transgenic and knockout mouse models for pulmonary hypertension: role of BMPR2 Part I: Genetically manipulated mouse models of pulmonary vascular disease and lung injury

摘要

Mutations of the bone morphogenetic protein type II receptor (BMPR2) gene were identified in the patients with pulmonary hypertension a decade ago. However, the pathogenesis of the disease remains to be elucidated because of the complex roles of additional genetic and/or environmental factors in the onset of the disease. Genetically modified mice for the BMPR2 gene were reported in the past several years. These findings reveal a crucial role of the BMPR2 gene in the development of pulmonary hypertension.