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Detrimental consequences of the paracetamol tablet elastic relaxation during ejection.

机译:扑热息痛片弹射过程中弹性松弛的有害后果。

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BACKGROUND: It is generally accepted that the tablet elastic relaxation during compaction plays a vital role in undermining the final tablet mechanical integrity. One of the least investigated stages of the compaction process is the ejection stage. METHOD: This work has successfully monitored the paracetamol tablet dimensional changes during ejection using noncontact dimensional measuring devices. The extent of the tablet damage was physically viewed by examining the presence of cracks on the tablet side surfaces upon complete ejection from the die cavity. RESULTS: Damaged tablets were obtained when the paracetamol tablets exhibited comparatively high elastic relaxation during the ejection stage of the compaction process. CONCLUSION: Hence, this work presents evidences of the detrimental consequences of the paracetamol tablet elastic relaxation during ejection on its final mechanical integrity..
机译:背景:人们普遍认为,压实过程中的片剂弹性松弛在破坏最终的片剂机械完整性方面起着至关重要的作用。压实过程中研究最少的阶段之一是喷射阶段。方法:这项工作已经成功地使用非接触式尺寸测量设备监测了对乙酰氨基酚片剂在喷射过程中的尺寸变化。通过检查从模腔完全弹出时片剂侧面上是否存在裂纹来物理上观察片剂损坏的程度。结果:当扑热息痛片在压实过程的弹射阶段表现出较高的弹性松弛时,会获得破损片。结论:因此,这项工作提供了对乙酰氨基酚片剂弹射过程中弹性松弛对其最终机械完整性的不利影响的证据。

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