Gastrointestinal Factor GDDR Attenuates Epithelial-Mesenchymal Transition in Gastric Cancer via Inhibiting AKT Signal

Fang Cheng; Zhang Ziqiang; Liu Chaoxu; Wang Gang; Wang Fei; Zhao Zhanwei; Li Wenhui; Hua Jin; Shuang Jianbo; Du Jianjun

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Gastrointestinal Factor GDDR Attenuates Epithelial-Mesenchymal Transition in Gastric Cancer via Inhibiting AKT Signal

机译：胃肠因子GDDR通过抑制AKT信号减弱胃癌的上皮-间质转化

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The gastric dramatic down-related gene (GDDR) is an abundantly expressed secretory protein in normal gastric epithelia, while its expression is distinctly decreased in gastric cancer. However, the role of GDDR in gastric cancer remains poorly understood.

机译：胃急剧下降相关基因（GDDR）是正常胃上皮细胞中大量表达的分泌蛋白，而在胃癌中其表达明显降低。但是，GDDR在胃癌中的作用仍知之甚少。

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来源
《Digestive Diseases and Sciences》 |2016年第7期|共9页
作者
Fang Cheng; Zhang Ziqiang; Liu Chaoxu; Wang Gang; Wang Fei; Zhao Zhanwei; Li Wenhui; Hua Jin; Shuang Jianbo; Du Jianjun;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Gastric cancer; GDDR; Tumor suppressor; Epithelial-mesenchymal transition; Akt;

机译：胃癌;GDDR;抑癌剂;上皮-间质转化;Akt;

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专利

1. Gastrointestinal Factor GDDR Attenuates Epithelial-Mesenchymal Transition in Gastric Cancer via Inhibiting AKT Signal [J] . Fang Cheng, Zhang Ziqiang, Liu Chaoxu, Digestive Diseases and Sciences . 2016,第7期

机译：胃肠因子GDDR通过抑制AKT信号减弱胃癌的上皮-间质转化
2. Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-beta/beta-catenin signaling and epithelial-mesenchymal transition [J] . Zhang Bin, Yang Yan, Shi Xiaoting, Cancer letters . 2015,第2期

机译：质子泵抑制剂pan托拉唑通过抑制Akt /GSK-β/β-catenin信号传导和上皮-间质转化来消除对阿霉素耐药的胃癌细胞的侵袭
3. Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-beta/beta-catenin signaling and epithelial-mesenchymal transition [J] . Zhang Bin, Yang Yan, Shi Xiaoting, Cancer letters . 2015,第2aPta2期

机译：质子泵抑制剂PantoPrazole通过抑制AKT / GSK-Beta /β-catenin信号传导和上皮间充质转换而废除亚霉素抗性胃癌细胞侵袭性
4. Novel Therapeutics for Inhibiting Tumor Epithelial-Mesenchymal Transition (EMT), a Key Driver of Metastasis and a Mechanism of Drug-Resistance [C] . Sergej M. Kiprijanov, Gro Gausdal, Tone Sal, PEGS . 2014

机译：抑制肿瘤上皮 - 间充质转换（EMT），转移的关键驱动器和抗药性机制的新型治疗剂
5. Autocrine and Paracrine Signaling Regulates Breast Cancer Stem Cells and Epithelial-Mesenchymal Transition in Inflammatory Breast Cancer [D] . Valeta, Amanda. 2016

机译：自分泌和旁碱基信号调节炎症乳腺癌中的乳腺癌干细胞和上皮 - 间充质转换
6. Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer [O] . Jiahui Xu, Deying Liu, Huilin Niu, 2017

机译：白藜芦醇通过调节胃癌中的PTEN / Akt信号通路抑制上皮-间质转化（EMT）从而逆转阿霉素耐药性
7. Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer [O] . Jiahui Xu, Deying Liu, Huilin Niu, 2017

机译：白藜芦醇通过调节胃癌中的PTEN / Akt信号通路抑制上皮-间质转化（EMT），从而逆转阿霉素耐药性

Gastrointestinal Factor GDDR Attenuates Epithelial-Mesenchymal Transition in Gastric Cancer via Inhibiting AKT Signal

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