Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats

Carvalho Nathalia S.; Silva Monica M.; Silva Renan O.; Nicolau Lucas A. D.; Araujo Thiago S. L.; Costa Douglas S.; Sousa Nayara A.; Souza Luan K. M.; Soares Pedro M. G.; Medeiros Jand Venes R.

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Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats

机译：辛伐他汀对阿仑膦酸盐致大鼠胃黏膜损伤的保护作用

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摘要

It has been reported that simvastatin, a statin commonly prescribed for its anti-inflammatory and antioxidant effects, has gastroprotective effects in indomethacin and ethanol-induced gastric ulcers. However, the effects of simvastatin on alendronate-induced gastric mucosal injury remain unexplored.

机译：据报道，辛伐他汀是一种常用的他汀类药物，具有抗炎和抗氧化作用，在消炎痛和乙醇引起的胃溃疡中具有胃保护作用。然而，辛伐他汀对阿仑膦酸盐诱发的胃粘膜损伤的作用尚待探索。

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来源
《Digestive Diseases and Sciences 》 |2016年第2期| 共10页
作者
Carvalho Nathalia S.; Silva Monica M.; Silva Renan O.; Nicolau Lucas A. D.; Araujo Thiago S. L.; Costa Douglas S.; Sousa Nayara A.; Souza Luan K. M.; Soares Pedro M. G.; Medeiros Jand Venes R.;
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正文语种 eng
中图分类消化系及腹部疾病 ;
关键词
Simvastatin; Biphosphonate; Gastric damage; Antioxidant; Anti-inflammatory;

机译：辛伐他汀;双膦酸盐;胃损伤;抗氧化剂;消炎;

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1. Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats [J] . Carvalho Nathalia S., Silva Monica M., Silva Renan O., Digestive Diseases and Sciences . 2016 ,第2期

机译：辛伐他汀对阿仑膦酸盐致大鼠胃黏膜损伤的保护作用
2. Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles [J] . Kaikai Bai, Bihong Hong, Ran Tan, International Journal of Nanomedicine . 2020 ,第1期

机译：硒纳米粒子嵌入的壳聚糖微球及其对大鼠酒精诱导的胃粘膜损伤的影响：硒纳米粒子的快速制剂，口服递送和胃保护潜力
3. Protective effects of alginate–chitosan microspheres loaded with alkaloids from Coptis?chinensis Franch. and Evodia rutaecarpa (Juss.) Benth. (Zuojin Pill) against ethanol-induced acute gastric mucosal injury in rats [J] . Qiang-Song Wang, Xiao-Ning Zhu, Heng-Li Jiang, Drug Design, Development and Therapy . 2015 ,第9期

机译：海藻壳聚糖微球对黄连生物碱的保护作用。和Evodia rutaecarpa（Juss。）Benth。左劲丸对乙醇诱导的大鼠急性胃黏膜损伤的保护作用
4. Cyto protective effect of bisbenzyl N′-(indol-3-ylmethylene)-hydrazinecarbodithioato-nickel(II) against ethanol-induced gastric mucosal injury in rats [C] . Mughrabi Fathi Farag, Hashim Harita, Ameen Mahmood, 2010 International Conference on Science and Social Research . 2010

机译：双苄基N'-（吲哚-3-基亚甲基）-肼甲二硫代-镍（II）对乙醇诱导的大鼠胃黏膜损伤的细胞保护作用
5. Oxidative injury in the reperfused rabbit heart and the cardioprotective effects of flavin reductase substrates. [D] . Mack, Christopher Paul. 1995

机译：再灌注兔心脏的氧化损伤和黄素还原酶底物的心脏保护作用。
6. Protective Effects of Methanol Extract of Vernonia amygdalina (del.) Leaf on Aspirin-Induced Gastric Ulceration and Oxidative Mucosal Damage in a Rat Model of Gastric Injury [O] . Modinat A. Adefisayo, Rufus O. Akomolafe, Olumide S. Akinsomisoye, 2018

机译：扁桃（Vernonia amygdalina（del。））叶甲醇提取物对阿司匹林诱导的胃溃疡大鼠胃溃疡和氧化性粘膜损伤的保护作用
7. Protective Effects of Methanol Extract of Vernonia amygdalina (del.) Leaf on Aspirin-Induced Gastric Ulceration and Oxidative Mucosal Damage in a Rat Model of Gastric Injury [O] . Modinat A. Adefisayo, Rufus O. Akomolafe, Olumide S. Akinsomisoye, 2018

机译：vernonia amygdalina（Del.）叶对阿司匹林诱导胃损伤胃溃疡的甲醇提取物的保护作用

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Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats

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