The Synthesis and Antimicrobial Activity of gamma-Butyrolactone Derivatives

摘要

This paper examines the synthesis of gamma-butyrolactone compounds 2,3,4,5,and 9,and their potential antimicrobial nature and ability.The structures of all the compounds mentioned above were determined and confirmed with elemental analyses,and IR,.~1H-NM-R,and ~(13)C-NMR spectroscopy.The in vitro antimicrobial activity of compounds 2,3,4,5,and 9 was examined and evaluated against the following pathogens:Enterobacter aerogenes,Enterobacter cloacae,Escherichia coli,Pseudomonas aeruginosa,Staphylococcus aureus,Staphylococcus epidermidis,Streptococcus agalactiae,Aspergillus niger,and Candida albicans.Compound 5(20 mg/mL)demonstrated high antimicrobial activity against S.epidermidis,which was closely comparable to the antimicrobial activity of streptomycin.