Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety

摘要

We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD_(50) . The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide~R and Lidocaine~R as positive antiarrhythmic controls.