Synthesis of new pyridoquinoxalines, thienopyridoquinoxalines and pyrimidothienopyridoquinoxalines.

摘要

Synthesis of 3-chloro-2-cyanoquinoxaline (1) and its reactions with sodium azide, guanidine hydrochloride, semicarbazide and thioheterocycles have been investigated (2-7). Also, the reaction of the chloro compound 1 with cyanoacetamide or cyanothioacetamide gave the pyrido[2,3-b]quinoxaline derivatives 8, 9. Compound 9 was used as a key intermediate to produce the more polyheterocyclic systems 10-18.