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Chemoprotective effects of ethanolic extract of neem leaf against MNNG-induced oxidative stress.

机译:印em叶乙醇提取物对MNNG诱导的氧化应激的化学保护作用。

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摘要

We evaluated the modifying effects of ethanolic extract of neem leaves (Azadirachta indica A. Juss) on oxidative stress induced by the potent gastric carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in male Wistar rats. The extent of lipid peroxidation and the status of the antioxidants superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione S-transferase (GST) were used as intermediate endpoints of chemoprevention. Three different concentrations of ethanolic neem leaf extract (100, 200 and 400 mg kg(-1) body weight) were administered by intragastric intubation (i.g) for five consecutive days followed by MNNG (i.g) 1.5 h after the final administration. Enhanced lipid peroxidation was accompanied by compromised antioxidant defences in the stomach, liver and erythrocytes of MNNG-treated rats. Pretreatment with ethanolic neem leaf extract at a dose of 200 mg/kg body weight (bw) significantly lowered the concentration of lipid peroxides and increased antioxidant levels. Our results demonstrate that neem leaf exerts its chemoprotective effects on MNNG- induced oxidative stress by decreasing lipid peroxidation and enhancing the antioxidant status.
机译:我们评估了印度of叶乙醇提取物(Azadirachta indica A. Juss)对雄性Wistar大鼠强胃癌致癌物N-甲基-N'-硝基-N-亚硝基胍(MNNG)诱导的氧化应激的修饰作用。脂质过氧化的程度和抗氧化剂超氧化物歧化酶(SOD),过氧化氢酶(CAT),还原型谷胱甘肽(GSH),谷胱甘肽过氧化物酶(GPx)和谷胱甘肽S-转移酶(GST)的状态被用作化学预防的中间终点。通过胃内插管(i.g)连续五天施用三种不同浓度的乙醇印em叶提取物(分别为100、200和400 mg kg(-1)体重),然后在最终施用后1.5小时进行MNNG(i.g)施用。脂质过氧化作用的增强伴随着MNNG治疗大鼠的胃,肝和红细胞中抗氧化防御能力的削弱。用乙醇印em叶提取物以200 mg / kg体重(bw)的剂量进行预处理可显着降低脂质过氧化物的浓度并增加抗氧化剂的水平。我们的结果表明印ne叶通过减少脂质过氧化并增强抗氧化剂状态,对MNNG诱导的氧化应激发挥化学保护作用。

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