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Tup/Islet1 integrates time and position to specify muscle identity in Drosophila

机译:Tup / Islet1整合时间和位置以指定果蝇中的肌肉身份

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摘要

The LIM-homeodomain transcription factor Tailup/Islet1 (Tup) is a key component of cardiogenesis in Drosophila and vertebrates. We report here an additional major role for Drosophila Tup in specifying dorsal muscles. Tup is expressed in the four dorsal muscle progenitors (PCs) and tup-null embryos display a severely disorganized dorsal musculature, including a transformation of the dorsal DA2 into dorsolateral DA3 muscle. This transformation is reciprocal to the DA3 to DA2 transformation observed in collier (col) mutants. The DA2 PC, which gives rise to the DA2 muscle and to an adult muscle precursor, is selected from a cluster of myoblasts transiently expressing both Tinman (Tin) and Col. The activation of tup by Tin in the DA2 PC is required to repress col transcription and establish DA2 identity. The transient, partial overlap between Tin and Col expression provides a window of opportunity to distinguish between DA2 and DA3 muscle identities. The function of Tup in the DA2 PC illustrates how single cell precision can be reached in cell specification when temporal dynamics are combined with positional information. The contributions of Tin, Tup and Col to patterning Drosophila dorsal muscles bring novel parallels with chordate pharyngeal muscle development.
机译:LIM同源域转录因子Tailup / Islet1(Tup)是果蝇和脊椎动物心脏发生的关键组成部分。我们在这里报告果蝇Tup在指定背肌中的其他主要作用。 Tup在四个背肌祖细胞(PCs)中表达,tup-null胚胎显示出严重紊乱的背肌结构,包括背DA2向背外侧DA3肌肉的转化。这种转化与在collier(col)突变体中观察到的从DA3到DA2转化是相互的。 DA2 PC可以从瞬时表达Tinman(Tin)和Col的成肌细胞群中选择,它可以产生DA2肌肉和成年肌肉前体。DA2PC中锡激活tup可以抑制结肠转录并建立DA2身份。 Tin和Col表达之间的瞬时,部分重叠提供了一个机会窗口,可以区分DA2和DA3肌肉身份。 Tup在DA2 PC中的功能说明了在将时间动态与位置信息结合在一起时,如何在单元规范中达到单单元精度。 Tin,Tup和Col对模式果蝇背肌的贡献带来了与碳酸盐咽咽肌发育的新相似之处。

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